Zeolites of the Tatarsko-Shatrashan deposit as carriers of model albumin for promising adsorption of therapeutic proteins

Islamova R. R., Yakovleva G. Y., Tyurin A. N., Ilinskaya O. N., Lopatin O. N.

Zapiski RMO (Proceedings of the Russian Mineralogical Society). 2022. V. 151. N 1. P. 105-113

https://doi.org/10.31857/S0869605522010063

Language: Russian

Abstract

Zeolites are known as natural adsorbents capable for ion exchange. The zeolite – clinoptilolite from the Tatarsko-Shatrashan deposit in the Republic of Tatarstan was studied as a possible carrier of therapeutic proteins. The Tatarsko-Shatrashan deposit has been discovered in 1990s in Drozhzhanovsky region of Tatarstan. The area has the well-developed infrastructure; the deposit is characterized by significant reserves of zeolite, represented by clinoptilolite. Previous studies comparing the toxicity of zeolites – natrolite, chabazite and clinoptilolite showed that the latter has the lowest toxicity and is characterized by the strongest adsorption capacity and ion-exchange properties. The studied samples were taken from the most productive part of the ore-body and material was used in form of powder and granules. As an adsorbate, there was used the model protein – bovine serum albumin. The article analyzes the possibility of studied zeolites to be carriers of anionic albumin, presents the results of albumin loading / unloading, the release of residual organic substances from zeolite samples. The measured adsorption capacity revealed the optimal carrier sample with the highest porosity. This work is a part of the Kazan Federal University Strategic Academic Leadership Program.

Keywords: absorption capacity, cation exchange, zeolites, zeolite-bearing rocks, clinoptilolite, Tatarsko-Shatrashan deposit, therapeutic proteins, albumen